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WOMEN’S HEALTH PANELS

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Perimenopause Panel (E2, FSH, LH)

Postmenopause Panel (E2, P4)

Women’s Fertility Panel (5 biomarkers)

Women’s Health Hormone Panel (11 biomarkers)

Women’s Hormone Panel (E2, FSH, LH, Prolactin)

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Women’s Health Hormone Panel (11 biomarkers)

Test ID: A916

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Introduction

This comprehensive hormone test measures 11 biomarkers that influence overall female health. Results from this test can be used in conjunction with other medical evaluations for a thorough evaluation of general health and wellness.

Estradiol:
Estradiol (E2) is a hormone naturally produced in both genders, with much higher levels in females. Estradiol is essential for female reproductive health, and also plays important functions in the skeletal system, skin health, nervous system, and cardiovascular system. Abnormal estradiol levels can affect fertility, sex drive, muscle and bone mass, growth, and skin health.

Follicle-Stimulating Hormone
Follicle-stimulating hormone (FSH) is a hormone produced in the pituitary gland in both males and females. It works with luteinizing hormone (LH) to regulate development, growth, pubertal maturation, and reproductive processes. Abnormal FSH levels can be an indication of infertility.

Luteinizing Hormone
Luteinizing hormone (LH) is a hormone produced in the pituitary gland in both males and females. In females, an “LH surge” triggers ovulation. Abnormal LH levels can be indicative of polycystic ovary syndrome, reduced fertility, and increased miscarriage risk.

Progesterone
Progesterone (P4) is a female sex hormone, which is essential during pregnancy and also in other roles, including bone formation and blood flow. Abnormally low progesterone occurs in females whom have disorders of ovulation, and is associated with infertility, spontaneous abortion, and ectopic pregnancy.

Testosterone
Testosterone is the primary sex hormone in males, but it is also important in females. Testosterone is secreted from the ovaries in females. Abnormal testosterone levels can influence muscle mass, sleep, energy, fertility, skin health, and sex drive.

Dehydroepiandrosterone Sulfate (DHEA-S)
Dehydroepiandrosterone sulfate (DHEA-S) is an excellent indicator of adrenal hormone production. Although DHEA-S itself only has weak hormonal activity, it can be metabolized into more active androgens (e.g. testosterone) and estrogens (e.g. estradiol). DHEA-S also has neurosteroid activity, meaning it can influence brain function. Abnormal DHEA-S levels can affect age of puberty, menstruation, muscle mass, aging, and sex drive, and also increase the risk of diabetes, osteoporosis, and dementia.

Cortisol
Cortisol is a steroid hormone that is predominantly produced in the adrenal gland. It is widely known as the body’s stress hormone, but also influences various other functions throughout the body. Elevated cortisol can cause weight gain, high blood pressure, mood swings, and skin changes. Low cortisol can cause fatigue, weight loss, low blood pressure, and skin hyperpigmentation.

Thyroid Stimulating Hormone
Thyroid stimulating hormone (TSH) is a hormone produced in the pituitary gland. TSH variations influence thyroid hormone levels. Thyroid hormone levels may fluctuate due to stress, diet, medications, childbirth, and menopause. Hyperthyroidism (excess thyroid hormones) can cause a fast heart rate, high blood pressure, excess sweating, shaky hands, anxiety, and weight loss. Hypothyroidism (low thyroid hormones) slows down body functions, and causes fatigue, puffy eyes and face, dry hair and skin, constipation, slower heart rate, constantly feeling cold, confusion, and depression.

Free Thyroxine (T4)
Thyroxine (T4) is the major hormone produced by the thyroid gland. 

Free Triiodothyronine (T3)
Triiodothyronine (T3) is a hormone produced by the thyroid gland, usually through conversion of thyroxine (T4) to T3. 

Thyroid Peroxidase Antibodies (anti-TPO)
Thyroid peroxidase is a protein produced from cells in the thyroid gland. Thyroid peroxidase antibodies (anti-TPO) occur when the body’s own immune system attacks the thyroid and targets thyroid peroxidase. This occurs in autoimmune disorders targeting the thyroid gland, such as Hashimoto’s thyroiditis (causing hypothyroidism) and Graves’ disease (causing hyperthyroidism).

Pricing

$199

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What is Included?

Measurement of 11 important hormone levels with chemiluminescent microparticle immunoassays:

  • Estradiol
  • Follicle-Stimulating Hormone
  • Luteinizing Hormone
  • Progesterone
  • Testosterone
  • Dehydroepiandrosterone Sulfate
  • Cortisol
  • Thyroid Stimulating Hormone
  • Free Thyroxine
  • Free Triiodothyronine
  • Thyroid Peroxidase Antibodies

Turnaround Time

1 – 3 business days
The turnaround time is not guaranteed. The average turnaround time is 1 – 3 business days from the date that the sample arrives at the laboratory. Shipping time for the sample is not included. Additional time is required if the case requires confirmatory or reflex testing, or if the sample is insufficient, or if a recollection is required.

Related Documents

SPECIMEN REQUIREMENTS 

Preparation Before Specimen Collection

Wait until at least three months after the cessation of hormonal contraception or hormonal replacement therapy before collecting your blood sample for this test.

Collect blood sample in the morning before 10am after a period of 24 hours in which you have felt safe and calm with no unusual stress, injuries, or vigorous activity.

Specimen Type

Blood

Volume

50 μL in a microtainer

Container

Microtainer (regular blood tube)

Collection Method

This test requires a blood sample from a finger prick. All supplies for sample collection are provided in the kit.

  1. First wash and dry hands. Warm hands aid in blood collection.
  2. Clean the finger prick site with the alcohol swab and allow to air dry.
  3. Use the provided lancet to puncture the skin in one quick, continuous and deliberate stroke.
  4. Wipe away the first drop of blood.
  5. Massage hand and finger to increase blood flow to the puncture site. Angle arm and hand downwards to facilitate blood collection on the fingertip.
  6. Drip blood into the microtainer tube.
  7. Dispose of all sharps safely and return sample to the laboratory in the provided prepaid return shipping envelope.

NOTES: Avoid squeezing or ‘milking’ the finger excessively. If more blood is required and blood flow stops, perform a second skin puncture on another finger. Do not touch the fingertip.

Specimen Storage

Maintain specimen at temperatures between 2°C and 30°C during storage and transport.

Specimen Stability

Blood samples can be refrigerated or kept at room temperature for up to 7 days.

Causes for Rejection

  • Incorrect or incomplete patient identification
  • Incorrect specimen collection
  • Inappropriate storage and transport conditions
  • Incorrect specimen volume

TEST DETAILS

Purpose

To measure the levels of 12 important hormones in a blood sample to detect abnormal hormone levels and aid in the analysis of overall female health.

Limitations

  • This report is not intended for use in medico-legal applications.
  • These results should be interpreted in conjunction with other laboratory and clinical information.
  • Correct specimen collection and handling is required for optimal assay performance.
  • Assay interference may occur in specimens from individuals routinely exposed to animals or to animal serum products. Additional clinical or diagnostic information may be required for these specimens.
  • False results may occur in specimens from individuals that have received preparations of mouse monoclonal antibodies for diagnosis or therapy. Additional clinical or diagnostic information may be required for these specimens.
  • Results obtained from different assay methods should not be used interchangeably in serial testing.
  • Artificially elevated cortisol values may occur in individuals receiving fludrocortisone, prednisolone or prednisone.
  • Heterophilic antibodies present in the tested blood sample may interfere with the cortisol assay.
  • The presence of anti-TPO antibodies does not confirm autoimmune thyroid disease or abnormal thyroid function. Anti-TPO antibodies are frequently found in other autoimmune diseases, including Rheumatoid Arthritis, Addison’s Disease and Type I Diabetes, and may occur in up to 20% of asymptomatic individuals.

Methodology

Chemiluminescent microparticle immunoassays:
Alinity i Estradiol assay
Alinity i FSH assay
Alinity i LH assay
Alinity i Progesterone assay
Alinity i 2nd Generation Testosterone assay
Alinity i DHEA-S assay
Alinity i Cortisol assay
Alinity i TSH assay
Alinity i Free T4 assay
Alinity i Free T3 assay
Alinity i Anti-TPO assay

Reference Intervals

Estradiol:
Normal menstruating females
– Follicular phase: 20 – 350 pg/mL
– Mid-cycle: 150 – 750 pg/mL
– Luteal phase: 30 – 450 pg/mL
Postmenopausal females: ≤ 20 pg/mL

These reference ranges were obtained from Pagana KD, Pagana TJ, Pagana TN. Mosby’s Diagnostic & Laboratory Test Reference. 15th ed. St. Louis, Mo: Elsevier; 2021.

Follicle-Stimulating Hormone:
Normal menstruating females
– Follicular phase: 2.0 – 12.0 mIU/mL
– Mid-cycle: 4.0 – 36.0 mIU/mL
– Luteal phase: 1.0 – 9.0 mIU/mL
Postmenopausal females: 26.7 – 133.4 mIU/mL

These reference ranges were obtained from the Alinity i FSH package insert and “Laboratory Reference Ranges” from the Endocrine Society.

Luteinizing Hormone:
Normal menstruating females1:
– Follicular phase: 1.0 – 18.0 mIU/mL
– Mid-cycle peak: 20.0 – 80.0 mIU/mL
– Luteal phase: 0.5 – 18.0 mIU/mL
Postmenopausal females2: 14.2 – 52.3 mIU/mL

These reference ranges were obtained from:
1 “Laboratory Reference Ranges” from the Endocrine Society.
2 Rifai N, Horvath AR, & Wittwer C. (2018). Tietz textbook of clinical chemistry and molecular diagnostics (Sixth edition.). St. Louis, Missouri: Elsevier.

Progesterone:
Normal menstruating females
– Follicular phase: < 0.5 ng/mL
– Luteal phase: 3.0 – 25.0 ng/mL
Postmenopausal females: < 0.4 ng/mL
Pregnant females
– First trimester: 7.25 – 44.0 ng/mL
– Second trimester: 19.5 – 82.5 ng/mL
– Third trimester: 65.0 – 229.0 ng/mL

These reference ranges were obtained from Pagana KD, Pagana TJ, Pagana TN. Mosby’s Diagnostic & Laboratory Test Reference. 14th ed. St. Louis, Mo: Elsevier; 2019.

Total Testosterone:
Females:
14 – 18 years1: 18 – 57 ng/dL (0.62 – 1.98 nmol/L)
≥ 19 years2: 8 – 60 ng/dL (0.28 – 2.08 nmol/L)

These reference ranges were obtained from:
1 Raizman JE, et al. Pediatric reference intervals for calculated free testosterone, bioavailable testosterone and free androgen index in the CALIPER cohort. Clin Chem Lab Med. 2015 Sep 1;53(10):e239-43.
2 Endocrine Society

Dehydroepiandrosterone sulfate:
Females:
16 – 17 years: 152 – 595 µg/dL
18 – 30 years: 45 – 380 µg/dL
31 – 50 years: 12 – 379 µg/dL
Postmenopause: 30 – 260 µg/dL

These reference ranges were obtained from Rifai N, Horvath AR, & Wittwer C. (2018). Tietz textbook of clinical chemistry and molecular diagnostics (Sixth edition.). St. Louis, Missouri: Elsevier.

Cortisol:
Before 10 am: 3.7 – 19.4 μg/dL
After 5 pm: 2.9 – 17.3 μg/dL

These reference ranges were obtained from the Alinity i Cortisol package insert.

Thyroid Stimulating Hormone:
0.35 – 4.94 μIU/mL

This reference range was obtained from the Alinity i TSH package insert.

Free Thyroxine:
0.70 – 1.48 ng/dL

This reference range was obtained from the Alinity i Free T4 package insert.

Free Triiodothyronine:
1.58 – 3.91 pg/mL

This reference range was obtained from the Alinity i Free T3 package insert. 

Thyroid Peroxidase Antibodies:
< 5.61 IU/mL

This reference range was obtained from the Alinity i Anti-TPO package insert.